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29 Apr ' 07:17
- Placental trophoblast inclusions have been related to autism risk in the child Anderson et al, 2007. Walker et al, 2013
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28 Mar ' 18:03
- maternal autoantibodies that target foetal brain proteins Braunschweig et al, 2008
- Maternal autoantibodies associated with autism spectrum disorders may affect brain development Nordahl et al, 2013
View Stats -
06 Feb ' 08:39
CDH9 CDH10 MACROD2 PARD3B PPP2R5C SEMA5A TAF1C TAS2R1
Rare mutations ASMT CHD8, DYRK1A, GRIN2B, KATNAL2, POGZ, and SCN2A, Buxbaum et al, 2012
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24 Nov ' 23:51
- Borrelia burgdorferi and tick-borne diseases (Lyme disease) have been associated with Autism and Bransfield 2012
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11 Oct ' 08:44
- Low levels of plasma EGF Onore et al, 2012
- Low plasma levels of platelet endothelial adhesion molecule-1 and P-selectin Onore et al, 2012
- High plasma levels of complement factor 1 in autistic children Momeni et al, 2009
- Glutathione imbalance and oxidative stress in peripheral immune cells Rose et al, 2012
- In newborns who later develop autism, decreased levels of T helper-1(Th-1)-like cytokines (i.e. Iinterferon gamma) and Th-2like cytokines (i.e. IL-4, IL-10) suggest a depressed or hypoactive immune cell activity during the neonatal period Abdallah et al, 2012
- Low plasma levels of immunoglobulins IgG and IgM Heuer et al, 2012
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14 Sep ' 10:11
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11 Aug ' 11:12
- A humoral immunity profile, described by three binary variables, IgA < 0.97 g/l, IgE > 36 IU/ml, and IgG > 6.3 g/l, was able to identify children with autism Wasilewska et al, 2012.
- Fever during pregnancy increases the risk of autism in the offspring - an effect reduced in those taking antipyretics Zerbo et al, 2012
- . Low brain levels of glutathione have also been reported Chauhan et al, 2012
- High plasma levels of thioredoxin , thioredoxin reductase and peroxiredoxins (PRDX1 and PRDX3) have been recorded in autistic children together with a reduction in plasma glutathione s transferase activity Al-Yafee et al, 2011
- Plasma and urinary oxalate levels have been reported as increased in autism spectrum disorders Konstantynowicz et al, 2011
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26 Apr ' 02:53
- Maternal diabetes and obesity have been associated with autism in the offspring Krakowiak et al, 2012
- Prenatal Polycyclic Aromatic Hydrocarbon (PAH) Exposure has been associated with autism and related disorders Perera et al, 2012
- Prenatal exposures to lacquer, varnish, or xylene have been associated with autism McCanlies et al, 2012
- High fructose corn syrup has been linked to the development of autism and related disorders Dufault et al, 2012
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04 Feb ' 02:45
- Borrelia burgdorferi and tick-borne diseases have been associated with Autism Bransfield et al, 2008
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03 Jan ' 18:03
Follow PolygenicPathways GWAS from Genome.Gov CDH9 CDH10 MACROD2 PPP2R5C SEMA5A TAS2R1
Children with autism were more likely to have mitochondrial dysfunction, mtDNA overreplication, and mtDNA deletions
- High fasting serum homocysteine and low folate and vitamin B12 levels could be used as clinical biomarkers for an early diagnosis and management of autism Ali et al, 2011.
Blood levels and other physiology
- Children with autism had much lower levels of total short chain fatty acids including lower levels of acetate, proprionate, and valerate
- Plasma levels of chemokines involved in the T-helper cell immune system and hematopoiesis were lower in the children with Autism compared with unrelated siblings without Autism Manzardo et al, 2011
Toxins
- DDT (the pesticide dichlorodiphenyltriichloroethene , has been associated with autism Audouze and Grandjean 2011
- Organochlorine pesticide applications--specifically dicofol and endosulfan--occurring immediately before and during central nervous system embryogenesis have been associated with the subsequent development of autism spectrum disorders Roberts et al, 2007
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