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30 Apr ' 23:36
March 24, 2013 - Metabolic syndrome Nabipour et al, 2006
- Obesity Karjala et al, 2011
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03 Jan ' 18:38
September 29, 2011 Need KEGG mapping: AIM2 AKT1 APOBEC1 ATR CTSB ENDOG IFI16 MSN MTOR NFKB1 PC (pyruvate carboxylase ) PCDC4 PDZD8 SNF2H TLR3 TOR1A ZBP1 ZMAT3 Phosphatidylcholine phosphatidylserine Current interactions ~ 483 with thanks to the many who have sent reprints.
, ER, lysosome (
protein kinase D1 Involved in the traffic of viral capsids from the trans-golgi network to the cell membrane
proteasome (prosome, macropain) subunit, alpha type, 7 Binds to
SUMO1/sentrin specific peptidase 1 Recruited to
Seven in absentia homolog degrades ICP0
AIM2 absent in melanoma 2 : Immune sensor for viral DNA Unterholzner et al, 2010
IFI16 interferon, gamma-inducible protein 16: Immune sensor for viral DNA Unterholzner et al, 2010
TLR3toll-like receptor 3 deficiency is an important determinant of herpes simplex virus 1 encephalitis Guo et al, 2011
ZBP1 Z-DNA binding protein 1 (DNA-dependent activator of interferon regulatory factors): intracellular sensor for DNA viruses Furr et al, 2011
MTOR mechanistic target of rapamycin (serine/threonine kinase) : activated by the us3 kinase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 : activation is inhibited by the virion host shut off protein Cotter et al, 2011
TOR1A Plays a role in nuclear egress Maric et al, 2011
BCL2-associated agonist of cell death Phosphorylated by tegument kinase
BCL2-associated X protein HSV-1 infection blocks
BH3 interacting domain death agonist Phosphorylated by tegument kinase
caspase 3, apoptosis-related cysteine peptidase US3
CASP8 and FADD-like apoptosis regulator The latency transcript encodes
cystatin C Blocks HSV-1 replication
glioma tumor suppressor candidate region gene 2 Binds to
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) Degrades
homeodomain interacting protein kinase 2 Binds to tegument protein
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) interacts with the viral US3 protein Wang et al, 2011
programmed cell death 6 Virion component
transforming growth factor, beta 1 Downregulated by a microRNA encoded by the LAT transcript
SMAD family member 3 Downregulated by a microRNA encoded by the LAT transcript
chromosome 9 open reading frame 9 binds to UL25
CHK2 checkpoint homolog (S. pombe)
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04 Sep ' 12:49
September 4, 2011 Need KEGG mapping AKT1 APOBEC1 ATR CTSB ENDOG MSN MTOR PC (pyruvate carboxylase ) PDZD8 SNF2H ZMAT3 Phosphatidylcholine phosphatidylserine Current interactions ~ 477 with thanks to the many who have sent reprints.
MSN Moesin modifies infectivity Henning et al, 2011
PDZD8 PDZ domain containing 8: moesin binding protein with antiviral properties Henning et al, 2011
Mitochondrial respiration is inhibited by the US3 protein between complexes II and III Derakhshan et al,2006 See KEGG Mitochondrial respiration
aryl hydrocarbon receptor nuclear translocator-like (Bmal1) Binds to
ATR (ataxia telangiectasia and Rad3 related) and ATRIP are recruited to replication compartments
ATR interacting protein Infection results in the sequestration of
RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae) Binds to ICP8
calcium binding and coiled-coil domain 2 Binds to
centromere protein B, 80kDa Degraded by the proteasome:
clock homolog (mouse) stabilised by the virus (see ARNTL)
CREB binding protein Binds to
CREB/ATF bZIP transcription factor Binds to tegument protein
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked Virion component
E1A binding protein p300 Binds to
general transcription factor IIB Binds to tegument protein
general transcription factor IIH, polypeptide 1, 62kDa Binds to
general transcription factor IIi Binds to ICP8
heterogeneous nuclear ribonucleoprotein L Binds to HSV-1 Thymidine kinase gene
heterogeneous nuclear ribonucleoprotein K Binds to IE63
Mdm1 nuclear protein homolog (mouse) ICP22
mediator complex subunit 8 Binds to UL14
mediator complex subunit 25 Binds to tegument protein
nuclear RNA export factor 1
poly(A) binding protein, cytoplasmic 1 Binds to ICP27 and tegument protein
proliferating cell nuclear antigen Binds to
promyelocytic leukemia Degraded by
polymerase (DNA directed), alpha 1, catalytic subunit Binds to
replication protein A1, 70kDa RPA2
runt-related transcription factor 3 Binds to UL14
RuvB-like 1 (E. coli) Binds to ICP8
SP100 nuclear antigen Binds to
SRSF protein kinase 1 Binds to ICP27
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa Binds to tegument protein
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa Binds to tegument protein
TIA1 cytotoxic granule-associated RNA binding protein Binds to the virion host shutoff (Vhs) tegument protein (
THO complex 4 (Aly/ref) Binds to ICP27
topoisomerase (DNA) II alpha 170kDa
zinc finger protein 36, C3H type, homolog (mouse) Binds to tegument protein
activity-dependent neuroprotector homeobox Binds to ICP8
AT rich interactive domain 3A (BRIGHT-like) degraded by ICP0
DEK oncogene Binds to ICP8
nucleosome assembly protein 1-like 1 Binds to ICP8
retinoblastoma binding protein 4 [ Binds to ICP8
SERPINE1 mRNA binding protein 1 Binds to ICP8
SIN3 homolog A, transcription regulator (yeast) Binds to ICP8
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 Binds to ICP8
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Binds to ICP8
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Binds to ICP8
matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 bBinds to ICP8
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 Binds to ICP8
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 Binds to ICP8
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 Binds to ICP8
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 Binds to ICP8
structural maintenance of chromosomes 1A or
suppressor of Ty 16 homolog (S. cerevisiae) Binds to ICP8
APEX nuclease (multifunctional DNA repair enzyme) 1 UL2
Bloom syndrome, RecQ helicase-like Binds to ICP8
BMI1 polycomb ring finger oncogene binds to the latent genome
breast cancer 1, early onset Binds to ICP8
DNA methyltransferase 1 associated protein 1 Binds to ICP8
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 Binds to ICP8
ligase III, DNA, ATP-dependent Complexes with
minichromosome maintenance complex component 2 Binds to ICP8
MRE11 meiotic recombination 11 homolog A (S. cerevisiae) Binds to ICP8
RAD50 homolog (S. cerevisiae) Binds to ICP8
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) Binds to ICP8
mutS homolog 3 (E. coli) Binds to ICP8
mutS homolog 6 (E. coli) Binds to ICP8
poly (ADP-ribose) polymerase 1
protein kinase, DNA-activated, catalytic polypeptide Binds to ICP8
Werner syndrome, RecQ helicase-like Binds to ICP8
X-ray repair complementing defective repair in Chinese hamster cells 1 Complexes with
X-ray repair complementing defective repair in Chinese hamster cells 4 Involved in viral DNA replication
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) Binds to origin of replication
X-ray repair complementing defective repair in Chinese hamster cells 6 Binds to origin of replication
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29 Aug ' 07:48
August 29, 2011 If you know of other direct interactions, (or corrections) please with Pubmed ID, host gene symbol/accession number and viral interacting protein. Thank you.
Need KEGG mapping AKT1 APOBEC1 ATR CTSB ENDOG MTOR PC (pyruvate carboxylase ) ZMAT3 Phosphatidylcholine phosphatidylserine Current interactions ~ 475 with thanks to the many who have sent reprints.
Many risk factors implicated in Alzheimer's disease are able to reactivate herpes simplex ISRN Neurology, 2011binds to Glycoprotein D[22] PVRL1 is cleaved by ADAM10 Kim et al, 2010
Gamma-secretase (a complex of anterior pharynx defective 1 homolog APH1A, nicastrin NCSTN, the presenilin enhancer PSENEN and presenilins PSEN1 or PSEN2) cleaves a number of viral receptors including PVRL1, SDC1 and SDC2 , as well as APP (reviewed in Lleó and Saura, 2011).
Amyloid precursor protein: Involved in fast anterograde transport of Herpes simplex ( squid axon); Major component of viral particles also involved in transport in human epithelial cells Cheng et al, 2011
Entry receptor Arii et al, 2010
Annexin 2 Virion component
PC HSV-1 increases anapleurotic influx to the Kebs cycle via pyruvate carboxylase, feeding pyrimidine biosynthesis.Vastag et al, 2011
AKT1 Us3 kinase is an AKT1 mimic Norman and Sarnow, 2010
conserved helix-loop-helix ubiquitous kinase (I-kappa-B kinase-alpha) binds to gamma 34.5 protein,
Casein kinase Virion component
MTOR activated by the us3 kinase Chuluunbaatar et al, 2010
PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide activated directly by VP11/12 Wagner and Smiley, 2011
and to ICP8
SRSF3 serine/arginine-rich splicing factor 3 Involved in viral RNA export Escudero-Paunetto et al, 2010
SRSF7 serine/arginine-rich splicing factor 7 Involved in viral RNA export Escudero-Paunetto et al, 2010
ATR and ATRIP are recruited to replication compartments Mohni et al, 2010
CLOCK stabilised by the virus (see ARNTL)Kalamvoki and Roizman, 2010
ZMAT3 zinc finger, matrin-type 3 phosphorylated by US3 Erazo et al, 2011
ARID3A degraded by ICP0
ENDOG endonuclease G cleaves a sequence of the viral genome Huang et al, 2002
NR3C1 glucocorticoid receptor binds to origin of replication site involved in the enhancement of replication by dexamethasoneHardwicke and Schaffer, 1997
RUVBL1Taylor and Knipe, 2004
U2AF1 binds to VP22
AICDA activation-induced cytidine deaminase edits the viral genome Suspène et al, 2011
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 edits HSV-1 viral DNA Gee et al, 2011
APOBEC3C : apolipoprotein B mRNA editing enzyme edits viral DNA also APOBEC3A, APOBC3G Suspène et al, 2011
EBF1 early B-cell factor 1 binds to ICP0 promoter Devireddy and Jones, 2000
SCXA binds to VP22
THRB Thyroid hormone receptor beta Binds to the LAT promoter and controls LAT and
Histone H1 (HIST1H1A H1F0 HIST1H1D HIST1H1E HIST1H1B ) Binds to viral genome
HIST3H3
Histone H4 HIST4H4 Bind to Viral genome
lysine (K)-specific demethylase 1A (histone demethylase) Recruited to viral intermediate early promoters, an effect inhibted by monoamine oxidase inhibitors
CTSB cathepsin B cleaves the origin binding protein Link et al, 2007
Cell cycle
ATM ataxia telangiectasia mutated: ICP0 transfection or infection induces ATM-dependent phosphorylation of CHEK2 and CDC25C Li et al, 2008
CDC25C cell division cycle 25 homolog C Li et al, 2008
CHEK2 checkpoint homolog Li et al, 2008
Adrenaline can reactivate the virus : Viral reactivation can be blocked by propanolol (beta adrenergic receptor antagonist) Hill et al, 1996Gebhardt and Kaufman 1995
Activators of thecapsaicinreceptor
Histone deacetylase inhibitors sodium butyrate and trichostatin A can reactivate the virus in neuronal cells
Cyclic AMP reactivates and cyclic GMP inhibits viral reactivation Foster et al, 1989
Dipyridamole( a thromboxane synthase inhibitor TBXAS1 ) inhibits viral reactivation Tenser et al, 2001 Fitzpatrick and Stringfellow, 1983
Lysophosphatidic acid can reactivate the virus Martin et al, 1999
Nicotine patches reactivate the virus in latently infected rabbits Myles et al, 2003 an effect blocked by bupropion( a dopamine/noradrenalinne uptake blocker) Myles et al, 2004
Caffeic acid and hot water extracts of coffee grinds inhibit viral replicationIkeda et al, 2011
or with interferons alpha and beta
IDO1 (indoleamine 2,3-dioxygenase 1) (activated by IFNG) and TDO2 (tryptophan 2,3-dioxygenase activation have general antiviral and antibacterial effects which are blocked by tryptophan Adams et al, 2004Schmidt et al, 2009
Brazilian propolis: a resinous mixture that bees collect from tree buds, sap, or other plant sources Shimizu et al, 2011
Cajanus Cajan extracts
Carissa Edulis extracts
Curcumin decreases HSV-1 infectivity
Cyanovirin-N displays anti HSV-1 and anti HIV-1 properties
Lithium carbonate inhibits viral infection Amsterdam et al, 1996
Neem extracts have antiviral activity
Extracts of marine alga Symphyocladia Latiusculapossess antiviral activity and
Resveratrolcan inhibit viral replication
Thai medicinal plant extracts including Moringa oleifera, Aglaia odorata and Vanilla.denticulata are active in vitro and in vivo
Viral infection internalises sodium channels
No vaccine yet:Clinical trials
TLR3 Audry et al, 2011
TRAF3 Audry et al, 2011
UNC93B1 Audry et al, 2011
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24 Jun ' 15:23
June 24, 2011 Currently ~443
ARID3A ARRB2 CASP8 CHUK CCL3 CCL4 CCL5 CRBN C9orf9 DCAF8 EIF2A IKKB INSM1 MED8 NBM RNF10 Phosphatidylcholine phosphatidylserine PLA2 PTK2B RIPK1 RUNX3 SCXA SIAH1 SMURF2 Sphingomyelin
CASP8 caspase 8, apoptosis-related cysteine peptidase binds to herpes simplex ribonucleotide reductase R1 Dufour et al, 2011
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 binds to herpes simplex ribonucleotide reductase R1 Dufour et al, 2011
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21 Jun ' 09:13
June 21, 2011 Currently ~441 with thanks to the many who have sent reprints.
ARID3A ARRB2 CHUK CCL3 CCL4 CCL5 CRBN C9orf9 DCAF8 EIF2A IKKB INSM1 MED8 NBM RNF10 Phosphatidylcholine phosphatidylserine PLA2 PTK2B RUNX3 SCXA SIAH1 SMURF2 Sphingomyelin
Phosphatidylcholine plays an important role in the binding of glycoproteins B and H to lipid membranes in the fusion process Galdiero et al, 2010
Sphingomyelin and phosphatidylserine are incorporated into HSV-1 virions van Genderen et al, 1994
Phospholipase A2 (calcium-dependent unspecified form) copurifies with the Herpes simplex Fc receptor Lehtinen et al, 1988
Interferon gamma blocks viral reactivation (per se)
interleukin 18 protects mice against viral infection
nerve growth factor maintains latency in peripheral neurones
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16 Jun ' 01:38
June 15, 2011 Currently ~439
ARID3A ARRB2 CHUK CCL3 CCL4 CCL5 CRBN C9orf9 DCAF8 EIF2A IKKB INSM1 MED8 NBM RNF10 PTK2B RUNX3 SCXA SIAH1 SMURF2
C9orf9 binds to UL25 Zhang et al, 2011
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05 Jun ' 15:36
June 4, 2011 Currently ~438
ARID3A ARRB2 CHUK CCL3 CCL4 CCL5 CRBN DCAF8 EIF2A IKKB INSM1 MED8 NBM RNF10 PTK2B RUNX3 SCXA SIAH1 SMURF2
SIAH1 Sevein in absentia homolog degrades ICP0Nagel et al, 2011
SMURF2 binds to VP22
EIF2A eukaryotic translation initiation factor 2A, 65kDa binds to ICP34.5Li et al, 2011
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27 May ' 00:14
May 27, 2011 Currently ~436
ARID3A ARRB2 CHUK CCL3 CCL4 CCL5 CRBN DCAF8 IKKB INSM1 MED8 NBM RNF10 PTK2B RUNX3 SCXA SMURF2
INSM1 insulinoma-associated 1 binds to ICP0 promoter Kamakura et al, 2011
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22 May ' 09:35
LoadingMay 22, 2011 Currently ~435
ARID3A ARRB2 CHUK CCL3 CCL4 CCL5 CRBN DCAF8 IKKB MED8 NBM RNF10 PTK2B RUNX3 SCXA SMURF2
ARID3A degraded by ICP0 Fukoyo et al, 2011
NBMNibrin Binds to UL12 Balasubramanian et al, 2011
MRE11, NBM and RAD50 are part of the MRN complex involved in DNA repair
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